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Casomorphin/Gliadorphin Peptides LC-MS/MS Assay

LC-MS/MS assay intended for the quantitative determination of casomorphin/gliadorphin peptides in stabilized urine.

SKU: KMR8000 Category:


Exorphins are bioactive peptides which can react with opiate receptors.

Casomorphin (BCM7 from casein) and gliadorphin-7 (from gluten) have been widely studied and are linked to gastrointestinal, neurological, and neuro-developmental disorders.
These short peptides are usually broken down by the enzyme dipeptidyl peptidase IV (DPPIV). In people with autism, schizophrenia and other neurological disorders, either a genetic deficiency or inhibition of this enzyme (e.g. by medication treating type 2 diabetes, mercury or yeast) can occur. In both ways, this proteolytic enzyme cannot act properly and leaves incompletely digested peptides behind, which are able to pass the blood-brain barrier after the uptake from the intestinal lining into the bloodstream. In the brain, these bioactive peptides can bind to opiate receptors and mimic the effects of opiate drugs like heroine and morphine. This can result in change of behavior, lack of focus and attention, sleepiness and even aggression and self-abuse.

Wheat and milk allergies are associated casomorphin/gliadorphin problems. Even if no milk or wheat allergies occur, some people can still react negatively to these peptides.
Children with autism and ADHS can benefit from an elimination diet – gluten-free, casein-free (GfCf) diet. Physical and mental health can be improved. This test for casomorphin/gliadorphin peptides is superior because no nutrional regimen prior to sample collection, is required.

  • Product Code:


  • Brand:

    Immundiagnostik AG

  • Assay Type:

    LC-MS/MS (Liquid Chromatography Tandem Mass Spectrometry)

  • Sample Types(s):
  • Regulatory Status:

    Research Use Only