Description
Anti-human neuronal transglutaminase IgG (anti-hnTG IgG) ELISA particularly detects antibodies to TG6 in human serum.
Celiac disease is the most common chronic disease of the small intestine. Gluten induces inflammation of the small intestinal mucosa, which can lead to the complete degradation of the small intestine villi. In addition, celiac disease is a gluten-induced autoimmune disease which is characterised by auto-antibodies to TG2 (tissue transglutaminase).
Autoantibodies directed against neuronal transglutaminase (TG6) have been detected in sera from patients with neurological disorders (e.g. ataxia, neuropathies, cerebral palsy, or stiff-person syndrome). TG6 autoantibodies may be present in celiac disease patients in addition to TG2 autoantibodies but have also been found in TG2 autoantibody-negative sera and in sera from patients without enteropathy (i.e. without celiac disease). Accordingly, TG6 autoantibodies can develop independently of celiac disease.
