Description
Studies have shown that tissue transglutaminase (tTG) is the predominant endomysial auto antigen characteristic for celiac disease.
In most celiac patients, usually several disorders are observed, such as malabsorption, infertility, osteoporosis, and delayed growth in children. It has also been widely reported that celiac disease is associated with many autoimmune diseases like Dermatitis herpetiformis (Duhring’s disease), diabetes mellitus, rheumatoid arthritis, IgA-nephritis, neuro-psychiatric disorders, Hashimoto-Thyroiditis, Basedow’s disease and an increased risk of developing malignant T cell lymphoma. Because the prevalence of associated autoimmune diseases in most cases is high, it is advisable to determine the auto antibodies against tissue transglutaminase (tTG) as a marker for celiac disease.