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Amyloid-β (x-42) ELISA

Enzyme immunoassay for the quantitative measurement of Amyloid-beta (x-42) variants cleaved at the N terminal side.

SKU: JP27711 Category:

Description

The plaques which appear in the brains of Alzheimer’s disease (AD) patients are mostly constituted by the amyloid-beta protein (Aβ).

Amyloid-beta is a peptide which consists of 40 or 42 (43) amino acids, and reports show that this is cleaved from beta (β) and gamma (γ) secretase from the amyloid precursor protein (APP). Reports have shown many variants of amyloid-beta exist and are clarified into the culture supernatant from the APP cDNA transfected mouse neuroblastoma cell. Furthermore, in 1995, a dominant and differential deposition of distinct amyloid-beta peptide species, amyloid-beta (N3pE), in senile plaques was found by Saido et al. This modified molecule, starting at the 3rd amino terminal residue, glutamate, was discovered to convert to pyroglutamate through intramolecular dehydration. Previously sold as JP27711 Amyloid-beta (1-42) ELISA.

  • Product Code:

    JP27711

  • Brand:

    TECAN (IBL International GmbH)

  • Assay Type:

    ELISA (Enzyme Immunoassay)

  • Sample Types(s):
  • Area of Interest:
  • Regulatory Status:

    Research Use Only