Description
Myostatin belongs to the transforming growth differentiation factor-ß (TGF-ß) super family.
Increased myostatin immuno-reactivity or expression has been observed in HIV-infected men with muscle wasting, after prolonged bed rest in young men and in older men and women with muscle wasting. Others have found that myostatin deficiency inhibits adipogenesis in vivo, even when mice are fed a high-fat diet. Transgenic overexpression of myostatin pro-peptide, which inhibits myostatin signaling, also inhibits body fat gain with a high-fat diet. Similar alterations in myostatin signaling are associated with changes in body fat among humans. It has been reported that myostatin-levels are regulated by aerobic exercise. Moreover, myostatin is in the causal pathway of acquired insulin resistance with physical inactivity.
