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S100A12 ELISA

Enzyme immunoassay intended for the quantitative determination of S100A12 (Calgranulin C, EN-RAGE).

SKU: KR6939 Category:

Description

Members of the S100 protein family are low molecular mass acidic proteins characterised by cell-type-specific expression and the presence of 2 EF-hand calcium binding domains.

The S100 proteins or calgranulins are expressed in activated granulocytes under conditions of chronic inflammation. It is reported that RAGE is a central cell surface receptor for S100A12, which is referred to as EN-RAGE (Extracellular Newly identified RAGE-binding protein), and related members of the S100/calgranulin super family. Interaction of S100A12 with cellular RAGE on endothelium, mononuclear phagocytes, and lymphocytes triggered cellular activation, with generation of key pro-inflammatory mediators. Since S100A12 is secreted by activated neutrophilic granulocytes and acts as a proinflammatory mediator, it can be used as marker for diagnosis and therapeutic control of various inflammatory diseases.

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  • Product Code:

    KR6939

  • Brand:

    Immundiagnostik AG

  • Assay Type:

    ELISA (Enzyme Immunoassay)

  • Sample Types(s):

    Serum

  • Area of Interest:

    Digestive Diseases

  • Regulatory Status:

    Research Use Only