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Hepcidin 25 LC-MS/MS Assay

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LC-MS/MS assay intended for the quantitative determination of hepcidin.

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SKU: KMR4000 Categories: ,

Description

Hepcidin-25 is a cysteine-rich peptide that is produced in the liver from an 84-amino acid precursor, pre-hepcidin.

So far, four isoforms have been characterised, which are distinguished by amino-terminal truncations: hepcidin-20, -22, -24 and -25. Hepcidin-20 and -25 are the two main forms consisting of 20 and 25 amino acids, respectively. Mass spectrometric analysis allows the differentation of these two isoforms and thus the selective determination of hepcidin-25. The natively folded hepcidin-25 contains eight cysteines linked by intramolecular disulfide bridges and regulates, among other things, the absorption of iron into the body.
Binding of hepcidin-25 to ferroportin, the iron export channel, eventually leads to lyosomal degradation of ferroportin. This inhibitory binding prevents the absorption of iron into the bloodstream. Hepcidin-25 can be used as a predictor of iron absorption. Hepcidin-25 enables the differentation of iron deficiency anemia (IDA) from anemia in chronic diseases (ACD) and ACD/IDA. It also predicts the response to oral iron therapy and thus provides valuable information for the treatment of patients.

  • Product Code:

    KMR4000

  • Brand:

    Immundiagnostik AG

  • Assay Type:

    LC-MS/MS (Liquid Chromatography Tandem Mass Spectrometry)

  • Sample Types(s):

    Serum, Plasma

  • Regulatory Status:

    Research Use Only