Description
Symmetric dimethylarginine (SDMA) is a methylated derivative of arginine which is strictly eliminated by renal extraction.
SDMA plasma level is strongly correlated to renal function. Also, there are suggestions that increased SDMA correlates with total sequential organ failure, indicating both renal and hepatic failure and an increased cardiovascular risk. Studies have shown that SDMA concentrations correlated highly with inulin clearance, as well as with various clearance estimates combined and serum creatinine. This shows that SDMA exhibits properties of a reliable marker of renal dysfunction.
