Description
alpha-klotho (α-Klotho) was originally characterized as an aging suppressor gene.
Low α-klotho levels are often associated with age-related diseases. α-Klotho and FGF23 are the main mediators of calcium and phosphate homeostasis. Any kind of disturbance, such as a reduced or increased production of α-Klotho, leads to metabolic bone disorders. The absence of α-Klotho leads to a substantially lower bone density than usual. In addition, α-Klotho is produced exclusively in the kidneys and brain. Studies have revealed that α-klotho levels are significantly decreased in the serum at an early stage in chronic kidney disease.
