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sAPP Total High Sensitive ELISA

Enzyme immunoassay for the quantitative determination of total soluble Amyloid Precursor Protein (sAPP).

SKU: JP27731 Category:

Description

It is known that amyloid-beta, which is the major constituent of senile plaques, is produced from amyloid-beta Precursor Protein (APP), which exists in three main isoforms, namely APP695, APP751, and APP770, by the beta-secretase (BACE1) and subsequently the gamma-secretase.

The production of soluble APP (sAPP) by beta-secretase cleavage is the first step in APP processing. Furthermore, it is has been shown that a specific APP gene mutation exists in individuals who suffer early-onset familial Alzheimer’s disease, which is called Swedish mutation. This gene mutation is a double mutation at positions -1 to -2 from the β-secretase cleavage site (Lysine670→Asparagine and Methionine671→Leucine). This kit can measure the total amount human soluble APP fragments in biological samples.

  • Product Code:

    JP27731

  • Brand:

    TECAN (IBL International GmbH)

  • Assay Type:

    ELISA (Enzyme Immunoassay)

  • Sample Types(s):
  • Area of Interest:
  • Regulatory Status:

    Research Use Only