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Anti-HMGB1, 2 Mouse IgG1 Monoclonal Antibody

Monoclonal antibody used in research related to HMGB1 – a signal for tissue damage and regeneration.

SKU: ST326052240 Category:

Description

HMGB1 and HMGB2 are chromatin-associated nuclear proteins that play an important role in transcription and DNA recombination.

HMG proteins contain a highly acidic C-terminal domain as well as two evolutionarily conserved high mobility group (HMG) box motifs as their N-terminus. HMG boxes are found in numerous DNA binding proteins and transcription factors and allow HMG proteins to bind and to bend DNA. Especially, HMGB1 is known as amphoterin, it mediates neurite outgrowth, and it binds receptors for advanced glycation end products (RAGE). Recently, HMGB1 was unexpectedly identified as a cytokine through studies of endotoxemia and sepsis. The antibody recognizes human, rabbit, bovine, pig, rat, and mouse HMGB1 and HMGB2. The specificity of the antibody was confirmed by western blot analysis. A hybridoma of the antibody was established by fusion of mouse myeloma cell P3U1 and BALB/c mouse spleen cell immunized with recombinant human HMGB1. This antibody was purified from the cell culture medium using Protein A Sepharose.

  • Product Code:

    ST326052240

  • Brand:

    TECAN (IBL International GmbH)

  • Assay Type:

    Antibody

  • Sample Types(s):
  • Regulatory Status:

    Research Use Only