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S 100 A12 (Calgranulin C EN-RAGE) ELISA
GASTROENTEROLOGY
Product Code: K6938

Alternative names: Calgranulin C, EN-RAGE
Members of the S100 protein family are low molecular mass acidic proteins characterized by cell-type-specific expression and the presence of 2 EF-hand calcium-binding domains. The S100 proteins or calgranulins are expressed in activated granulocytes under conditions of chronic inflammation.
Hofmann et al. (1999) reported that RAGE is a central cell surface receptor for S100A12, which they referred to as EN-RAGE (Extracellular Newly identified RAGE-binding protein), and related members of the S100/calgranulin super family.
Interaction of S100A12 with cellular RAGE on endothelium, mononuclear phagocytes, and lymphocytes triggered cellular activation, with generation of key pro-inflammatory mediators.

Diagnostic area GASTROENTEROLOGY

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