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Alpha-1 Antitrypsin Clearance ELISA
GASTROENTEROLOGY
Product Code: K6752

The Alpha-1 Antitrypsin ELISA is intended for the quantitative determination of alpha-1 antitrypsin in stool. Alpha-1 Antitrypsin is synthesized primarily in the liver but also to a small extent in intestinal macrophages, monocytes, and intestinal epithelial cells. Since alpha-1 antitrypsin is relatively resistant against enzymatic digestion, the secreted amount in stool reflects the internal concentration of the protein. Elevated alpha-1 antitrypsin concentration in stool is a widely recognized marker for intestinal protein loss and for an increased mucosal permeability.

In clinical routine, an elevated alpha-1 antitrypsin clearance value (the ratio of alpha-1 antitrypsin in stool vs. serum samples) suggests excessive gastrointestinal protein loss.


Diagnostic area GASTROENTEROLOGY
Brand Immundiagnostik
Regulatory status Research Use Only
Assay type Immunoassay

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