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Beta-Defensin 2 ELISA (Stool)
GASTROENTEROLOGY
Product Code: K6500

The beta-defensins are an integral part of the congenital immune system and contribute with their antimicrobial effect to the barrier function of intestinal epithelial cells. Defensins exert a variable degree of antimicrobial activity against bacteria, fungi, and some enveloped viruses. The expression of beta-defensins is induced by the pro-inflammatory cytokines and also through microorganisms (e.g. E. coli, H. pylori or P. aeruginosa). A beta-defensin 2 deficiency can be observed in the intestinal mucous of patients with Crohn's disease. The defense system of the mucous membrane is therefore restricted and allows an increased invasion of bacteria, which could possibly lead to an infection in these patients. Whether the beta-defensin 2 deficiency could even play a role in the development of Crohn's disease is currently being studied. As is the possibility that it is the probiotic bacterium which produces beta-defensin.


Diagnostic area GASTROENTEROLOGY
Brand Immundiagnostik
Regulatory status Research Use Only
Assay type Immunoassay

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